(385) 250-0900

About Us

Tissue Regeneration Sciences, Inc is an early stage biotechnology venture founded on the patented tissue regenerative technology of calreticulin. Our mission is to develop and commercialize healing and tissue regenerative technologies to improve patient quality of life.

Tissue Regeneration Sciences

TRS is devoted to developing and commercializing the results of years of research by Dr Leslie I Gold on the protein calreticulin.

About Tissue Regeneration Sciences (TRS)

An early stage biotechnology venture founded on the potent novel biotherapeutic, calreticulin, that heals wounds by tissue regeneration.

FIRST INDICATION: Developing the first topical drug treatment for diabetic foot ulcers (DFUs), a serious unmet medical need.

Core Tissue Regeneration Indications


Tissue regeneration of chronic cutaneous wounds including diabetic foot ulcers, pressure ulcers (bed sores), and venous stasis ulcers


Cosmetic soft tissue augmentation for the treatment of fine lines and wrinkles


Ophthalmic ulcers (e.g., corneal abrasions)


Tissue Reconstruction


Cartilage and bone regeneration


Regeneration of new hair follicles


Orphan indication of sickle cell skin ulcerations


Acute Wounds

Pre-Clinical FDA Trials

TRS is undertaking preclinical studies to enable filing INDs for initial indications of cutaneous tissue regeneration, soft tissue augmentation, and hair follicle neogenesis and to further understand mechanisms of action of calreticulin in the various indications.